Journal of the Serbian Chemical Society 2002 Volume 67, Issue 5, Pages: 325-329
https://doi.org/10.2298/JSC0205325K
Full text (
66 KB)
Cited by
An efficient synthesis of warfarin acetals on montmorillonite clay K-10 with microwaves
Krstić Ljubomir (Institute of Chemistry, Technology and Metallurgy - Center of Chemistry, Belgrade)
Sukdolak Slobodan (Faculty of Sciences - Department of Chemistry, Kragujevac)
Solujić-Sukdolak Slavica (Faculty of Sciences - Department of Chemistry, Kragujevac)
The microwave promoted reaction of warfarin with methanol, or ethanol, in the presence of montmorillonite clay K-10 as a catalyst, affords the corresponding acetals, 2-methoxy 2-methyl-4-phenyl-3,4-dihydro-2H-pyrano[3,2-c]chromen-5-one (2) and 2-ethoxy-2-methyl- 4-phenyl-3,4-dihydro-2H-pyrano[3,2-c]chromen-5-one (3) respectively, in good yields.
Keywords: warfarin, cyclic acetals, montmorillonite K-10, microwaves.